AdvanCell Isotopes
Radiopharmaceutical Generator
2024
Research, Concept, Development + Production
AdvanCell Isotopes
Commercial-Scale Production of Lead-212 for Targeted Alpha Therapies: Engineered to Triple Clinical Output in 24 Hours
The next-generation AdvanCell Generator is a compact, innovative device that enables the commercial-scale production of Lead-212 for targeted alpha therapies, which are potential best-in-class treatments for cancer. Through its modular system, it achieves commercial-scale production, creating unparalleled patient access to this exciting new class of life-saving therapies. Engineered to upscale clinical dose production while fitting within standard hot-cell cabinets, the AdvanCell Generator optimises space and enhances scalability with a precision-designed triple-stack configuration that triples clinical output within 24 hours. This setup allows each module to function independently or in synergy, providing flexibility in operation. The user-friendly interface and automated processes simplify the workflow, ensuring ease of use while consistently producing reliable outputs of Lead-212. This scalable production meets high commercial demand and improves societal health outcomes by providing timely access to novel targeted alpha therapies for patients who need it most.
Engineering Excellence
Fully automated, Mechanically operated, GMP-compliant process ensures consistent, high-quality alpha radioligand production.
Enhancing the AdvanCell Generator's capacity while fitting within a defined manufacturing environment required reducing its physical footprint and optimizing internal configurations. Seamless integration with a new external fluidics system was essential for ensuring GMP compliance. Non-metal components were selected to prevent trace metal contamination, maintaining the purity of the radiopharmaceuticals. Usability improvements included a user-friendly interface and automated processes that streamline operation. Safety features, such as shielding and multiple interlock systems, protect operators from radiation exposure in line with international standards. Front and side access panels were added to simplify maintenance, allowing for quick and safe servicing. The generator’s form maintains the brand’s modern, sophisticated design language, with its compact, modular structure finished in pristine white and stainless steel, ensuring it meets the professional standards and sterile requirements of medical environments. These advancements support the reliable, scalable production of Lead-212, essential for the next generation of targeted alpha therapeutics.
