Inspiring

Universal Spacer System

2024

Research, Concept, Development + Production

 

Inspiring Spacer

Universal Spacer System (USS): Revolutionising Delivery of Inhaled Therapies.

Inspiring is revolutionising inhaled drug delivery for those who need it most: More than 600 million people worldwide suffer from asthma, chronic obstructive pulmonary disease, cystic fibrosis and other lung conditions, most of whom use some form of inhaled drug delivery device. There is a critical need for new inhalation devices to improve drug delivery and ease of use for people who rely on inhaled therapies. 

Current Spacer systems on the market work only with MDI inhalers where their capacity to improve inhaled delivery of aerosolised drug into the lungs is limited. The confined space causes high impaction and particle retention rate, aerosol loss through the valve, and persisting requirements for optimal timing and technique results in highly variable and often ineffective doses delivered from these spacers. The patient / parent / observer also has no reference as to whether or not the drug has been inhaled.

Virtually all jet or vibrating mesh Nebuliser Systems (excluding expensive breath actuated nebulisers) are open-circuit systems where all aerosolised drug produced while the user is breathing out is lost to the outside environment (known as fugitive aerosol), resulting in wastage of up to two-thirds of the drug placed in the nebuliser. This potentially toxic fugitive aerosol is a safety concern for family members and hospital staff by contaminating the users environment, and increasing the risk of spread of infection from the user to nearby persons.

Medical Device Design and Development: Inhaled Drug Delivery Device

Complete Product Development: Industrial Design + Mechanical Engineering

 
 

Modular Inhalation System

The Inspiring USS efficiently delivers and controls aerosol medication during breathing.

The Inspiring Universal Spacer System works in conjunction with standard inhaled drug delivery devices (MDI or nebuliser). When the drug is expelled from the drug delivery device it enters a large volume spherical, non-static and hydrophobic silicone reservoir, where it remains in suspension until inhalation begins. As the user inhales, the drug passes from the reservoir through a bi-valved mouthpiece (and an optional facemask) and into the user’s mouth, collapsing the reservoir as the air/drug exits. This provides valuable visual feedback to the user that the dose had been delivered. 

During exhalation, the valve system in the mouthpiece prevents exhaled air from re-entering the reservoir by directing it to the outside. This allows the reservoir to re-expand and refill with aerosol in readiness for the next inhalation. This simple principle addresses the deficiencies of current spacers, resulting in dramatically improved ease-of-use, safety, efficiency, and consistency of drug delivery performance.

Another issue with existing spacers is portability and the knock on effects this has on compliance with using the device. As by its very nature the USS reservoir is collapsible, it can easily be stored in it’s accompanying carry case and transported discreetly.

 
 

Enhanced Delivery and Consistency

USS nebuliser delivers inhaled therapies consistently and efficiently, regardless of the user's breathing pattern.

The proprietary design of the USS includes a unique, thin-walled, spherical collapsible reservoir, which forms a buffer between the delivery devices and the user’s mouth. Material selection, engineering analysis and iterative prototype development and testing have been a key part of refining the specification of the USS to optimise performance. Performance testing of the USS versus a standard mesh nebuliser, showed that the USS delivered approximately 80% of the drug to the user, irrespective of a user’s breath pattern. This means that the delivered dose remains consistent regardless of how severe a user’s respiratory condition may be. A standard mesh nebuliser without the USS delivered approximately 25% of the drug to the users mouth, with the amount of drug delivered decreasing with the increased severity of the user’s respiratory condition, due to changes in their breath patterns.