Indee Labs: BioTools Innovator 2023
NEWS: BioTools Innovator 2023 - Indee Labs
BioTools Innovator 2023
Commercialisation Journey: BioTools Innovator 2023
Indee Labs is a biotechnology startup developing Hydropore, which enables modified immune cell research and development with improved yield and function using a simple workflow, commercial GMP-grade buffers and a small footprint.
Indee Labs, a biotechnology startup, is advancing their Hydropore™ platform—a ground-breaking non-viral technology that enhances immune cell modification with improved efficiency and safety. Hydropore™ utilises microfluidic vortex shedding (µVS) to introduce small molecules, nucleic acids, proteins, and gene-editing complexes into immune cells swiftly and effectively. This process preserves cell viability and functionality, making it a superior alternative to traditional methods. Hydropore™ stands out for its high-yield cell modification capabilities, enabling the transformation of millions to billions of immune cells in a short time. This innovation holds significant promise for advancing cancer therapies, improving diabetes management, and making treatments more accessible and cost-effective.
Design + Industry has played a pivotal role in Indee Labs' journey, providing expertise from brief inceptions across all major capacities: industrial design, electronics engineering, and prototype development to significantly improve the usability, aesthetics, and ultimately the commercialization of the Hydropore™ system.
Indee Labs is also a portfolio company of the BioTools Innovator, a program established to improve human health by accelerating the growth of life science tools and diagnostics. BioTools Innovator, powered by MedTech Innovator, connects industry leaders with emerging biotech companies for mentorship and support. The support provided by this program is pivotal for the next stages of Indee Labs' mission to revolutionize cell therapy research and clinical applications.
To learn more, visit indeelabs.com
Microfluidic Vortex Shedding (µVS): At the core of Hydropore™ is the use of microfluidic vortex shedding (µVS). This technique involves the controlled application of fluidic forces to immune cells.
Permeabilizing the Cell Membrane: Hydropore™ employs µVS to gently and temporarily disrupt the cell membrane of immune cells. This disruption creates temporary pores or openings in the cell membrane.
Payload Delivery: Once the cell membrane is permeabilized, Hydropore™ facilitates the rapid and efficient delivery of payloads into the immune cells. These payloads can include small molecules, nucleic acids (such as DNA or RNA), proteins, and gene-editing complexes.
Preserving Cell Viability and Functionality: Importantly, Hydropore™ accomplishes this payload delivery while maintaining the viability and functionality of the immune cells. Unlike some traditional methods that can harm or compromise the cells during modification, Hydropore™ minimizes the perturbation of immune cell states.
High-Yield Cell Modification: Hydropore™ enables the modification of a large number of immune cells within a short period. This high-yield capability is essential for the development and manufacturing of cell therapies.
